hg

Others

Surgery

Sedation

FLUMAZENIL (Antagonist)

 

Preparation:           

Glass Ampoules 500μg in 5ml

 

Half-life:                   

Shorter than Midazolam – Patient can re-sedate

 

Physiology:

 

Uses:                                 

Reversal agent for Midazolam

 

Pharmacology:               

Displaces Midazolam from receptors on GABA

 

Indication:      

  • Patient oversedated.

  • Slow recovery

 

Contraindications:

  • Allergic reaction to Benzodiazepine/Midazolam

  • Epileptics – rapid recovery can cause seizures

 

Advantages:           

  • Rapid recovery from sedation

 

Disadvantages:              

Shorter half-life than Midazolam, patient can re-sedate.

 

Dose:      

  • 200μg (2ml) over 15 seconds.

  • Review 60 seconds and titrate

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Author: Amelia Reed

Last update: 10/04/2015